Research Article
Therapeutic Outcomes of Patients with Multifocal Papillary Thyroid Microcarcinomas and Larger Tumors
Table 3
Clinical features of multifocal papillary thyroid cancer in nonremission or remission.
| | Clinical characteristics | All patients | Nonremission | Remission | value |
| | Patient number | 626 (100.0) | 131 (20.9) | 495 (79.1) | | | Gender, female | 499 (79.7) | 84 (64.1) | 415 (83.8) | <0.001 | | Age at diagnosis (year) | 46.5 ± 13.5 | 47.8 ± 17.1 | 46.1 ± 12.4 | 0.214 | | Mean tumor size (cm) | 2.1 ± 1.4 | 2.6 ± 1.7 | 2.0 ± 1.3 | <0.001 | | 1-month postoperative serum Tg level (ng/mL) | 184.2 ± 1551.1 | 770.2 ± 3286.7 | 25.3 ± 102.8 | <0.001 | | Operative method | | Total thyroidectomy | 595 (95.0) | 127 (96.9) | 468 (94.5) | 0.260 | | Less than total thyroidectomy | 31 (5.0) | 4 (3.1) | 27 (5.5) | | | TNM stage | | Stage I | 390 (62.3) | 53 (40.5) | 337 (68.1) | <0.001 | | Stage II | 58 (9.3) | 15 (11.5) | 43 (8.7) | 0.332 | | Stage III | 67 (10.7) | 14 (10.7) | 53 (10.7) | 0.995 | | Stage IV | 111 (17.7) | 49 (37.4) | 62 (12.5) | <0.001 | | Follow-up period (year) | 7.1 ± 5.3 | 7.4 ± 5.5 | 7.0 ± 5.3 | 0.478 | | Postoperative 131I accumulative dose (mCi) | 153.7 ± 222.2 | 384.2 ± 366.4 | 92.8 ± 95.5 | <0.001 | | Radiation therapy | 28 (4.5) | 27 (20.6) | 1 (0.2) | <0.001 | | 2nd primary cancer | 49 (7.8) | 15 (11.5) | 34 (6.9) | 0.083 | | Diabetes mellitus | 61 (9.7) | 13 (9.9) | 48 (9.7) | 0.938 | | Overall mortality | 49 (7.8) | 29 (22.1) | 20 (4.0) | <0.001 | | Cancer mortality | 25 (4.0) | 24 (18.3) | 1 (0.2) | <0.001 | | Disease-free | 221 (35.3) | 16 (12.2) | 205 (41.4) | <0.001 |
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Number (%); mean ± SD.
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