XRCC5 VNTR, XRCC6 -61C>G, and XRCC7 6721G>T Gene Polymorphisms Associated with Male Infertility Risk: Evidences from Case-Control and In Silico Studies

Table 1

Demographic and clinical characteristics of participants.

Variable	Control; ()	Patients			value
		Total; ()	AS; ()	Severe OS; ()	Control versus; total	Control versus; AS	Control versus; severe OS
Age (years: mean ± SD)	31.6 ± 4.4	32.3 ± 2.7	32.05 ± 4.1	31.8 ± 3.6	0.191	0.540	0.582
Body mass index (kg/m^2) (%)
≤24.9	27.1	25.8	23.5	28.9
25–34.9	66.3	64.04	64.7	63.1
≥35	6.5	10.1	11.7	7.8	0.201	0.119	0.689
Smoking (%)
Yes	30.8	34.8	37.2	31.5
No	69.1	65.1	62.7	68.4	0.401	0.257	0.904
Semen analysis (%)
(1) Sperm count ≤ 20 (million/mL)	0	100	100	100	<0.001	<0.001	<0.001
(2) Motility (grade a + b)
≥50	68.2	10.1	9.8	10.5
<50	31.7	89.8	90.1	89.4	<0.001	<0.001	<0.001
(3) Viscosity
≤30 min	57.9	73.03	72.5	73.6
>30 min	42.05	26.9	27.4	26.3	0.316	0.251	0.694
(4) Normal morphology
≥30%	34.5	13.4	11.7	15.78
<30%	65.4	86.5	88.2	84.2	0.001	0.004	0.004

AS: azoospermia, OS: oligozoospermia.