XRCC5 VNTR, XRCC6 -61C>G, and XRCC7 6721G>T Gene Polymorphisms Associated with Male Infertility Risk: Evidences from Case-Control and In Silico Studies
Table 2
Genotype and allele frequencies of XRCC5 VNTR gene polymorphisms in controls and infertile patients.
Genotype
Control
Patients
value [OR (95% CI )]
Study power %a
Total () n (%)
Total () n (%)
AS () n (%)
Severe OS () n (%)
Controls versus total patients
Controls versus AS
Controls versus severe OS
Controls versus total patients
Controls versus AS
Controls versus severe OS
0R/0R
4 (1.86)
11 (6.17)
7 (6.86)
4 (5.26)
49.03
48.45
23.85
0R/1R
12 (5.60)
21 (11.79)
13 (12.74)
8 (10.52)
0.510 [0.636 (0.165–2.445)]
0.519 [0.619 (0.144–2.659)]
0.360 [0.666 (0.128–3.469)]
51.85
50.14
24.19
1R/1R
17 (7.94)
33 (18.53)
22 (21.56)
11 (14.47)
0.531 [0.705 (0.195–2.552)]
0.668 [0.739 (0.185–2.945)]
0.589 [0.647 (0.133–3.141)]
84.01
87.39
31.32
0R/2R
23 (10.74)
16 (8.98)
6 (5.88)
10 (13.15)
0.039 [0.253 (0.068–0.937)]
0.014 [0.149 (0.032–0.682)]
0.299 [0.434 (0.090–2.094)]
5.109
19.25
5.054
1R/2R
64 (29.90)
39 (21.91)
22 (21.56)
17 (22.36)
0.014 [0.221 (0.066–0.744)]
0.015 [0.196 (0.052–0.735)]
0.080 [0.265 (0.060–1.173)]
38.46
28.53
18.35
2R/2R
83 (38.78)
51 (28.65)
27 (26.47)
24 (31.57)
0.014 [0.223 (0.067–0.739)]
0.011 [0.185 (0.050–0.684)]
0.095 [0.289 (0.067–1.243)]
51.44
50.39
15.53
0R/3R
—
—
—
—
—
—
—
—
—
—
1R/3R
3 (1.40)
—
—
—
0.570 [0.755 (0.286–1.991)]
0.130 [0.085 (0.003–2.072)]
0.238 [0.142 (0.005–3.642)]
10.33
−6.14
−3.894
2R/3R
8 (3.73)
7 (3.93)
5 (4.90)
2 (2.63)
0.142 [0.318 (0.068–1.468)]
0.224 [0.357 (0.067–1.879)]
0.191 [0.250 (0.031–1.998)]
3.348
3.566
7.091
3R/3R
—
—
—
—
—
—
—
—
—
—
0R carriers
39 (18.24)
48 (26.96)
26 (25.49)
22 (28.94)
0.039# [1.656 (1.025–2.676)]
0.136 [1.535 (0.872–2.699)]
0.050 [1.828 (0.998–3.348)]
49.40
27.39
43.89
0R noncarriers
175 (81.76)
130 (73.03)
76 (74.50)
54 (71.05)
49.50
27.41
43.94
1R carriers
96 (44.85)
93 (52.24)
57 (55.88)
36 (47.36)
0.145 [1.344 (0.902–2.004)]
0.067 [1.556 (0.968–2.502)]
0.495 [1.198 (0.714–2.009)]
27.14
40.07
3.265
1R noncarriers
118 (55.14)
85 (47.75)
45 (44.11)
40 (52.63)
27.14
40.07
3.265
2R carriers
178 (83.17)
113 (63.48)
60 (58.82)
53 (69.73)
<0.0001 [0.351 (0.219–0.562)]
<0.0001 [0.288 (0.169–0.492)]
0.013 [0.466 (0.2541–0.854)]
99.11
99.27
63.23
2R noncarriers
36 (16.82)
65 (36.51)
42 (41.17)
23 (30.26)
99.11
99.27
63.25
3R carriers
11 (5.14)
7 (3.93)
5 (4.90)
2 (2.63)
0.570 [0.755 (0.286–1.991)]
0.928 [0.951 (0.321–2.813)]
0.372 [0.498 (0.108–2.303)]
3.19
3.087
3.761
3R noncarriers
203 (94.85)
171 (96.06)
97 (95.09)
74 (97.36)
3.18
3.085
3.762
0R allele
43 (10.04)
59 (16.57)
33 (16.17)
26 (17.10)
42.06
29.04
31.04
1R allele
113 (26.40)
126 (35.39)
79 (38.72)
47 (30.92)
0.384 [0.812 (0.509–1.297)]
0.733 [0.911 (0.532–1.558)]
0.217 [0.687 (0.379–1.245)]
44.12
55.1
8.872
2R allele
261 (60.98)
164 (46.06)
87 (42.64)
77 (50.65)
0.0005 [0.458 (0.295–0.710)]
0.001 [0.434 (0.259–0.726)]
0.010 [0.487 (0.281–0.845)]
81.51
83.92
29.85
3R allele
11 (2.57)
7 (1.96)
5 (2.24)
2 (1.31)
0.142 [0.463 (0.166–1.293)]
0.372 [0.592 (0.187–1.871)]
0.136 [0.300 (0.061–1.464)]
4.507
4.188
2.69
aPower based on normal approximation with continuity correction. 0R carriers refer to individuals with the allele 0R including 0R/0R + 0R/1R + 0R/2R + 0R/3R, 1R carriers refer to individuals with allele 1R including 0R/1R + 1R/1R + 10R/2R + 1R/3R, 2R carriers refer to individuals with allele 2R including 0R/2R + 1R/2R + 2R/2R + 2R/3R, and 3R carriers refer to individuals with allele 3R including 0R/3R + 1R/3R + 2R/3R + 3R/3R. #We calculated value for the 0R carriers and compared the allele 0R carrier’s individuals in the controls and patients against the entire individual without the allele 0R in the controls and patients, respectively; the other value for the allele R carriers was calculated according to this formula.
