Central Precocious Puberty and Response to GnRHa Therapy in Children with Cerebral Palsy and Moderate to Severe Motor Impairment: Data from a Longitudinal, Case-Control, Multicentre, Italian Study
Table 2
Longitudinal evaluation of anthropometric features of patients with CPP at baseline (diagnosis of CPP) and during GnRHa treatment. H-TH SDS: height SDS adjusted for target height (TH).
Baseline
1st follow-up visit°
2nd follow-up visit°
Group A
Group C
Group A
Group C
Group A
Group C
Chronological age (CA)
6.42 ± 1.74
7.02 ± 0.79
7.50 ± 1.75°
8.02 ± 0.90°
8.59 ± 2.15°
8.69 ± 0.55°
Height SDS
−0.72 ± 1.86
0.75 ± 1.46^
−0.96 ± 1.86
0.87 ± 1.38^
−1.32 ± 1.63
0.76 ± 1.70^
H-TH SDS
−0.63 ± 1.94
1.56 ± 1.38^
−0.72 ± 1.90
1.68 ± 1.26^
−1.07 ± 1.83
1.48 ± 1.42^
Discrepancy between bone age (BA) and CA
1.74 ± 1.18
1.74 ± 1.57
1.07 ± 1.01°
1.65 ± 0.98
0.72 ± 0.65°
0.89 ± 0.43
Growth velocity (cm/years)
6.67 ± 1.22
9.1 ± 0.99
5.61 ± 1.99
6.70 ± 1.34
4.51 ± 3.04°
6.60 ± 1.30^
BMI SDS
0.67 ± 1.31
0.45 ± 0.82
0.15 ± 1.54°
0.57 ± 1.02
0.52 ± 1.21
0.24 ± 0.98
°Significant difference in the same group from baseline. ^Significant difference between the groups at the specific time point.
