Serum-Free Thyroxine Levels Were Associated with Pulmonary Hypertension and Pulmonary Artery Systolic Pressure in Euthyroid Patients with Coronary Artery Disease

Table 4

Multiple logistic regression analysis for pulmonary hypertension.

Independent variables	Model 1; OR (95% CI)	Model 2; OR (95% CI)	Model 3; OR (95% CI)
Gender	0.56 (0.31–0.99)	0.56 (0.32–0.99)	0.58 (0.33–1.02)
Age	1.06 (1.03–1.09)	1.06 (1.03–1.09)	1.06 (1.03–1.09)
BMI	1.01 (0.94–1.10)	1.02 (0.94–1.11)	1.02 (0.94–1.10)
SBP	0.99 (0.97–1.01)	0.99 (0.97–1.01)	0.99 (0.97–1.01)
Smoking	2.21 (1.09–4.46)	2.24 (1.11–4.55)	2.19 (1.08–4.44)
Hypertension	1.74 (0.93–3.28)	1.64 (0.87–3.10)	1.73 (0.92–3.25)
ACEI & ARB	0.96 (0.57–1.60)	0.93 (0.55–1.56)	0.94 (0.56–1.56)
CCB	0.78 (0.44–1.41)	0.76 (0.42–1.37)	0.78 (0.43–1.40)
Nitrates	1.08 (0.66–1.77)	1.07 (0.65–1.76)	1.07 (0.65–1.75)
LVEF	0.95 (0.93–0.97)	0.95 (0.93–0.97)	0.95 (0.93–0.97)
FT3	1.18 (0.79–1.82)	/	/
FT4	/	1.12 (1.01–1.25)	/
TSH	/	/	0.97 (0.84–1.12)

PH: pulmonary hypertension; BMI: body mass index; SBP: systolic blood pressure; FT₄: free thyroxine; FT₃: free triiodothyronine; TSH: thyroid-stimulating hormone; LVEF: left ventricular ejection fraction; CCB: calcium channel blockers; ACEI & ARB: ACE inhibitors and angiotensin II receptor antagonists. Independent variables included in the original model are as follows: model 1: FT₃, gender, age, BMI, smoking, LVEF, SBP, history of hypertension, CCB, ACE & ARB, and nitrates; model 2: FT₄, gender, age, BMI, smoking, LVEF, SBP, history of hypertension, CCB, ACE & ARB, and nitrates; and model 3: TSH, gender, age, BMI, smoking, LVEF, SBP, history of hypertension, CCB, ACE & ARB, and nitrates.