Research Article

Nonalcoholic Fatty Liver Disease and Associated Metabolic Risks of Hypertension in Type 2 Diabetes: A Cross-Sectional Community-Based Study

Table 3

Stratified analysis of NAFLD and the associated metabolic risk factors in type 2 diabetes with or without HTN.

ParametersType 2 diabetes ()OR (95% CI)
NBP ()HTN ()

Age (years)
45–55160 (42.2)218 (57.7)1
55–65182 (27.5)479 (72.5)1.930 (1.470, 2.533)
65–7568 (17.1)330 (82.9)3.548 (2.522, 4.992)
≥7533 (15.6)178 (84.4)3.852 (2.483, 5.977)

Anthropometric parameters
Waist circumference (cm)
 <90 M, <85 F224 (34.4)427 (65.6)1
 ≥90 M, ≥85 F207 (22.0)736 (78.1)1.921 (1.515, 2.435)
WHR
 <0.90 M, <0.85 F138 (33.8)270 (66.2)1
 ≥0.90 M, ≥0.85 F305 (24.6)935 (75.4)1.534 (1.185, 1.986)
BMI (kg/m2)
 <25.0250 (35.0)465 (65.0)1
 25.0–30.0153 (21.2)569 (78.8)2.294 (1.785, 2.948)
 ≥30.024 (14.0)148 (86.1)3.572 (2.230, 5.721)

Metabolic parameters
HOMA-IR
 <2.8260 (33.0)529 (67.1)1
 ≥2.8183 (21.3)676 (78.7)1.948 (1.540, 2.465)
HOMA-beta39.9 (22.8, 63.7)49.8 (30.5, 77.6)1.010 (1.006, 1.013)
FPG (mmol/L)7.1 (6.3, 8.2)7.2 (6.4, 8.4)1.007 (0.960, 1.057)
PPG (mmol/L)13.4 (11.3, 17)13.5 (11.4, 17)0.996 (0.974, 1.020)
FINS (mIU/L)7.3 (4.7, 11.4)9.4 (6.2, 14)1.008 (0.998, 1.019)
HbA1c (%)6.3 (5.8, 7.2)6.4 (5.9, 7.2)1.014 (0.936, 1.098)
TCH (mmol/L)
 <4.592 (24.8)279 (75.2)1
 ≥4.5351 (27.5)925 (72.5)0.843 (0.634, 1.121)
TG (mmol/L)
 <1.7277 (30.3)638 (69.7)1
 ≥1.7166 (22.7)566 (77.3)1.773 (1.396, 2.251)
HDL-C (mmol/L)
 <1.0439 (24.5)120 (75.5)
 ≥1.04404 (47.8)1084 (72.9)0.742 (0.500, 1.102)
LDL-C (mmol/L)
 <2.6149 (27.6)391 (72.4)1
 2.6–3.4172 (26.3)482 (73.7)1.115 (0.851, 1.461)
 ≥3.4122 (26.9)331 (73.1)1.104 (0.818, 1.491)
UA (μmol/L)
 ≤420 M, ≤360 F375 (28.7)934 (71.4)1
 >420 M, >360 F68 (20.1)270 (79.9)1.474 (1.079, 2.012)

Thyroid function
FT3 (pmol/L)4.9 (4.5, 5.4)5.0 (4.5, 5.4)1.211 (1.020, 1.437)
FT4 (pmol/L)15.8 (14.4, 17.2)15.8 (14.5, 17.4)1.019 (0.973, 1.067)
TSH (mIU/L)2.1 (1.4, 3.0)2.2 (1.6, 3.1)0.995 (0.966, 1.024)

Liver disease
Without NAFLD296 (37.5)494 (62.5)1
With NAFLD147 (21.5)536 (78.5)2.344 (1.736, 3.165)

Adjustment of sex, age, smoke, drinking, and family history of hypertension.
Bold values were used to indicate the significant results ().
NBP, normal BP; HTN, hypertension; M, male; F, female; WHR, waist-hip ratio; BMI, body mass index; HOMA-IR, homeostasis model assessment for insulin resistance index; HOMA-beta, homeostasis model assessment for beta cell function; FPG, fasting plasma glucose; PPG, postprandial plasma glucose; FINS, fasting plasma insulin; HbA1c, hemoglobin A1c; TCH, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; UA, uric acid; FT3, free triiodothyronine; FT4, free thyroxine; TSH, thyroid-stimulating hormone; and NAFLD, nonalcoholic fatty liver disease.