Elevated Squamous Cell Carcinoma Antigen, Cytokeratin 19 Fragment, and Carcinoembryonic Antigen Levels in Diabetic Nephropathy
Table 1
General characteristics of subjects included in the analysis.
Parameters
Control group
DM group
DN1 group
DN2 group
N (male/female)
90 (45/45)
96 (47/49)
88 (44/44)
77 (39/38)
UACR, mg/g
6.16 (4.91–7.96)
10.22 (6.76–14.07)
69.09 (42.10–136.47)†
796.80 (477.78–1874.10)†$
Age, yrs
63 (56–69)
63 (57–69)
64 (56–70)
63 (56–70)
Duration of diabetes, yrs
—
10 (6–16)
12 (8–16)
13 (9–18)
BMI, kg/m2
23.51 (22.09–25.51)
24.00 (21.84–27.17)
24.66 (22.98–27.60)
24.80 (23.15–27.80)
eGFR, ml/min/1.73m2
116.62 (100.71–136.27)
107.17 (92.23–125.11)
102.28 (85.56–120.36)
68.82 (45.12–87.16)†$
FPG, mmol/l
5.30 (5.00–5.50)
7.50 (6.30–8.60)
7.60 (6.40–9.10)
7.90 (6.50–9.20)
HbA1C, %
5.30 (5.10–5.50)
7.40 (6.50–8.20)
8.00 (7.10–9.20)†
8.10 (7.10–9.30)†
SBP, mmHg
120.0 (111.0–130.0)
130.0 (120.0–132.0)
130.0 (120.0–140.0)†
136.0 (130.0–146.0)†$
DBP, mmHg
75.0 (69.0–80.0)
80.0 (73.0–80.0)
80.0 (75.0–80.0)
80.0 (75.5–84.0)
Hypertension, %
—
21.9
31.8
42.9†
Use of ACEI/ARB, %
—
24.0
37.5†
44.2†
Current smoker, %
16.7
17.7
26.1
36.4†
Current drinker, %
8.9
10.4
14.8
26.0†
Data are summarized as median (interquartile range) for continuous variables or as number with proportion for categorical variables. DM: diabetes mellitus with normoalbuminuria; DN1: diabetes mellitus with microalbuminuria; DN2: diabetes mellitus with macroalbuminuria; UACR: urinary albumin to creatinine ratio; BMI: body mass index; eGFR: estimated glomerular filtration rate; FPG: fasting plasma glucose; HbA1C: glycated hemoglobin; SBP: systolic blood pressure; DBP: diatolic blood pressure; ACEI: angiotensin-converting enzyme inhibitors; ARB: angiotensin receptor blockers. versus control group; † versus DM group; $ versus DN1 group.
