Serum ZAG Levels Were Associated with eGFR Mild Decrease in T2DM Patients with Diabetic Nephropathy

Table 3

Unconditional logistic regression analysis of eGFR in T2DM patients with the lowest, middle, and highest serum ZAG levels.

	ZAG_3 level; OR (95% CI)
	Low	Median	High	P for trend
Number of subjects	145	147	146
Model 1	1.00	1.10 (0.67, 1.80)	1.94 (1.17, 3.23)	0.0094
Model 2	1.00	1.18 (0.70, 1.99)	1.87 (1.09, 3.22)	0.0228
Model 3	1.00	1.22 (0.71, 2.10)	1.90 (1.09, 3.32)	0.0233

Multivariate odds ratios (OR) and 95% confident intervals (CI) from unconditional logistic regression models were used in the analysis.
Model 1: basic model, adjusted for age group, gender, and education.
Model 2: further adjusted for BMI (<24 kg/m², ≥24 kg/m²), WC (<90 cm, ≥90 cm) in men and (<85 cm, ≥85 cm) in women, hypertension (none, yes), TC (<5.2 mmol/L, ≥5.2 nnol/L), TG (<1.7 mmol/L, ≥1.7 mmol/L), HbA1_C (≤7.0%, >7.0%), FPG (≤7.0 mmol/L, >7.0 mmol/L), based on Model 1.
Model 3: full model, further adjusted for uACR (<2.7 mg/mmol, ≥2.7 mg/mmol) and 25OHD (>50 nmol/L, ≤50 nmol/L) based on Model 2.