Melatonin and Angelman Syndrome: Implications and Mathematical Model of Diurnal Secretion

Table 2

Results of Mann–Whitney U test for the AG and CG groups (the statistically important values are in bold).

Model parameters	Median of the CG group	Median of the AG group	value
b1, minimum melatonin concentration (pg/mL)	6.16	7.83	0.6065
b2, melatonin release amplitude (pg/mL)	142.51	167.46	0.372
b3, phase shift of melatonin release (h)	1.38	3.59	0.0039
b4, estimated sleep duration (h)	7.07	8.05	0.0427
Maximum melatonin concentration (pg/mL)	152.14	175.69	0.372
DLMOon50 (h)	22.1	23.74	0.1592
DLMOoff50 (h)	5.2	8.72	0.0005
DLMOon25 (h)	21.33	22.69	0.2039
DLMOoff25 (h)	6.06	10.47	0.0004
Max gamma	1.81	2.65	0.3906

Time in decimal scale.