Melatonin and Angelman Syndrome: Implications and Mathematical Model of Diurnal Secretion

Table 3

Results of Mann–Whitney U test for the AG and EG groups (the statistically important values are in bold).

Model parameters	Median of the EG group	Median of the AG group	value
b1, minimum melatonin concentration (pg/mL)	5.84	7.83	0.7675
b2, melatonin release amplitude (pg/mL)	116.34	167.46	0.064
b3, phase shift of melatonin release (h)	2.34	3.59	0.0521
b4, estimated sleep duration (h)	7.32	8.05	0.0421
Maximum melatonin concentration (pg/mL)	117.38	175.69	0.0673
DLMOon50 (h)	23.02	23.74	0.298
DLMOoff50 (h)	5.83	8.72	0.0016
DLMOon25 (h)	22	22.69	0.3507
DLMOoff25 (h)	6.69	10.47	0.001
Max gamma	1.02	2.65	0.078

Time in decimal scale.