International Journal of Endocrinology

Clinical Study

Higher Ratio of Abdominal Subcutaneous to Visceral Adipose Tissue Related with Preservation of Islet β-Cell Function in Healthy Individuals

Table 2

Correlations coefficients of SAT, VAT, and SVR with glucose metabolism.


	Healthy group ()			MD group ()			Hyperglycemic group ()
	ASAT	VAT	SVR	ASAT	VAT	SVR	ASAT	VAT	SVR

Glucose profile
FPG	0.101	0.148	−0.086	0.017	0.179	−0.139	0.066	0.100	−0.094
PG_30min	0.09	0.193	−0.295	−0.092	0.303	−0.342	0.082	0.093	−0.037
PG_120min	0.106	0.186	−0.104	0.001	0.051	−0.022	−0.032	0.137	−0.185
Insulin resistance/sensitivity
HOMA-IR	0.325	0.369	−0.139	0.278	0.295	−0.053	0.307	0.459	−0.234
Matsuda index	−0.294	−0.384	0.172	−0.210	−0.361	0.159	−0.299	−0.467	0.237
Insulin secretion
HOMA-B	0.274	0.266	−0.064	0.287	0.174	0.050	0.255	0.321	−0.092
I0–30/G0–30	0.303	0.204	0.031	0.216	0.260	−0.080	0.199	0.333	−0.145
I_30–120/G_30–120	0.311	0.275	−0.019	0.188	0.276	−0.104	0.255	0.320	−0.075
Disposition indexes
Basal DI	−0.090	−0.147	0.091	−0.019	−0.176	0.137	−0.057	−0.097	0.097
Early-phase DI	0.011	−0.213	0.231	−0.006	−0.118	0.089	−0.098	−0.076	0.061
Late-phase DI	−0.045	−0.218	0.217	−0.079	−0.130	0.064	−0.081	−0.102	0.097

; ; . ASAT: subcutaneous adipose tissue; VAT: visceral adipose tissue; SVR: the ratio of SAT to VAT; FPG: fasting plasma glucose; PG_30min: 30 min plasma glucose during oral glucose tolerance (OGTT); PG_120min: 120 min plasma glucose during OGTT; HOMA-IR: homeostasis assessment insulin resistance; HOMA-B: HOMA β-cell function; Matsuda index was calculated as 10,000/([(FPG × fasting plasma insulin) × (mean glucose during OGTT × mean insulin during OGTT)]). Basal DI: basal disposition index (DI) was calculated as HOMA-B/HOMA-IR; I_0–30/G_0–30 was calculated as [(30 min insulin (INS) + FINS) × 30/2]/[(30 min plasma glucose (PG) + FPG) × 18 × 30/2]; early-phase DI was calculated as I_0–30/G_0–30 × Matsuda index. I_30–120/G_30–120 was calculated as [(30 min INS + 120 min INS) × 90/2]/[(30 min PG + 120 min PG) × 18 × 90/2]; late-phase DI was calculated as I_30–120/G_30–120 × Matsuda index.