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International Journal of Endocrinology
Volume 2017, Article ID 6372964, 6 pages
https://doi.org/10.1155/2017/6372964
Research Article

Pediatric TSH Reference Intervals and Prevalence of High Thyroid Antibodies in the Lebanese Population

1Department of Endocrinology, Faculty of Medicine, Saint Joseph University, Beirut, Lebanon
2Hormonology Laboratory, Hôtel-Dieu de France Hospital, Beirut, Lebanon

Correspondence should be addressed to Marie-Hélène Gannagé-Yared; bl.ude.jsu@deray.eneleheiram

Received 23 October 2016; Revised 11 November 2016; Accepted 20 November 2016; Published 18 January 2017

Academic Editor: Małgorzata Kotula-Balak

Copyright © 2017 Marie-Hélène Gannagé-Yared et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The aims of this study are to establish reference values for TSH in Lebanese schoolchildren; to look at the relationship between TSH and age, gender, BMI, socioeconomic status (SES), and thyroid antibodies (TAb); and to investigate the prevalence of abnormal TAb in this population. 974 Lebanese schoolchildren aged 8–18 years were recruited from 10 schools of different SES. Third-generation TSH, TPO-Ab, and Tg-Ab measurements were performed using the IMMULITE chemiluminescent immunoassay. The mean TSH is μUI/ml. TSH values are inversely correlated with age , are higher in boys than in girls (resp., and μUI/ml, ), and are positively correlated with BMI . They are also significantly higher in subjects from low-SES schools and in girls with positive TAb . In boys, TSH is independently associated with age, BMI, and schools’ SES (, , and , resp.) while in girls, the association is only significant for age and TAb ( and , resp.). The prevalence of TAb is 4.3% (3% for TPO-Ab and 2.1% for Tg-Ab). Our results showed higher TSH values in the pediatric Lebanese population compared to western populations. TSH varies according to age, gender, BMI, and SES and is associated in girls with TAb.