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International Journal of Endocrinology
Volume 2017 (2017), Article ID 6437542, 5 pages
https://doi.org/10.1155/2017/6437542
Research Article

Associations of Two Obesity-Related Single-Nucleotide Polymorphisms with Adiponectin in Chinese Children

1Department of Epidemiology, Capital Institute of Pediatrics, Beijing, China
2Department of Biochemistry, Capital Institute of Pediatrics, Beijing, China

Correspondence should be addressed to Jie Mi; moc.361.piv@imeij

Received 14 November 2016; Revised 20 February 2017; Accepted 21 February 2017; Published 15 March 2017

Academic Editor: Franco Veglio

Copyright © 2017 Lijun Wu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose. Genome-wide association studies have found two obesity-related single-nucleotide polymorphisms (SNPs), rs17782313 near the melanocortin-4 receptor (MC4R) gene and rs6265 near the brain-derived neurotrophic factor (BDNF) gene, but the associations of both SNPs with other obesity-related traits are not fully described, especially in children. The aim of the present study is to investigate the associations between the SNPs and adiponectin that has a regulatory role in glucose and lipid metabolism. Methods. We examined the associations of the SNPs with adiponectin in Beijing Child and Adolescent Metabolic Syndrome (BCAMS) study. A total of 3503 children participated in the study. Results. The SNP rs6265 was significantly associated with adiponectin under an additive model ( and 0.024, resp.) after adjustment for age, gender, and BMI or obesity statuses. The SNP rs17782313 was significantly associated with low adiponectin under a recessive model. No statistical significance was found between the two SNPs and low adiponectin after correction for multiple testing. Conclusion. We demonstrate for the first time that the SNP rs17782313 near MC4R and the SNP rs6265 near BDNF are associated with adiponectin in Chinese children. These novel findings provide important evidence that adiponectin possibly mediates MC4R and BDNF involved in obesity.