Amino Acid Signatures to Evaluate the Beneficial Effects of Weight Loss
Table 2
Amino acids associated with waist circumference and BMI in the Malmö Diet and Cancer Cardiovascular Cohort.
Amino acids
Model 1 (adjusted for age and gender)
Model 2 (adjusted for age, gender, SBP, AHT, and T2D status)
βWC (SE)
βBMI (SE)
βWC (SE)
βBMI (SE)
Alanine
3.359 (0.393)
<0.001
1.215 (0.153)
<0.001
3.337 (0.377)
<0.001
1.197 (0.148)
<0.001
Arginine
−0.452 (0.408)
0.268
−0.241 (0.158)
0.128
−0.407 (0.392)
0.299
−0.220 (0.152)
0.149
Asparagine
−2.800 (0.397)
<0.001
−0.996 (0.155)
<0.001
−2.137 (0.391)
<0.001
−0.822 (0.153)
<0.001
Glutamate
2.642 (0.401)
<0.001
0.791 (0.157)
<0.001
2.125 (0.393)
<0.001
0.591 (0.154)
<0.001
Glutamine
−2.029 (0.409)
<0.001
−0.780 (0.159)
<0.001
−1.613 (0.398)
<0.001
−0.632 (0.155)
<0.001
Glycine
−3.348 (0.413)
<0.001
−1.286 (0.160)
<0.001
−2.940 (0.403)
<0.001
−1.138 (0.157)
<0.001
Isoleucine
2.746 (0.448)
<0.001
0.849 (0.175)
<0.001
2.054 (0.448)
<0.001
0.594 (0.175)
0.001
Leucine
1.377 (0.447)
0.002
0.431 (0.174)
0.013
0.681 (0.443)
0.124
0.180 (0.172)
0.295
Lysine
0.615 (0.408)
0.133
0.231(0.158)
0.144
0.450 (0.393)
0.252
0.173 (0.153)
0.259
Methionine
0.670 (0.427)
0.117
0.191 (0.166)
0.249
0.632 (0.410)
0.124
0.168 (0.160)
0.293
Ornithine
−1.184 (0.409)
0.004
−0.467 (0.159)
0.003
−1.245 (0.393)
0.002
−0.482 (0.153)
0.002
Phenylalanine
2.726 (0.408)
<0.001
1.006 (0.159)
<0.001
2.584 (0.392)
<0.001
0.951 (0.153)
<0.001
Proline
1.081 (0.414)
0.009
0.405 (0.161)
0.012
1.128 (0.397)
0.005
0.422 (0.155)
0.007
Serine
−1.566 (0.411)
<0.001
−0.599 (0.160)
<0.001
−0.969 (0.404)
0.017
−0.382 (0.157)
0.015
Threonine
−1.512 (0.406)
<0.001
−0.541 (0.158)
0.001
−1.106 (0.396)
0.005
−0.396 (0.154)
0.01
Tryptophan
0.434 (0.428)
0.311
0.097 (0.166)
0.558
0.330 (0.411)
0.423
0.052 (0.160)
0.743
Tyrosine
3.835 (0.387)
<0.001
1.367 (0.152)
<0.001
3.586 (0.376)
<0.001
1.261 (0.148)
<0.001
Valine
3.021 (0.418)
<0.001
1.085 (0.163)
<0.001
2.408 (0.418)
<0.001
0.863 (0.163)
<0.001
DM-AA score
4.091 (0.406)
<0.001
1.425 (0.159)
<0.001
3.648 (0.170)
<0.001
1.256 (0.156)
<0.001
Models 1 and 2: linear regression analysis to test amino acids association with waist circumference and BMI; β: standardized regression coefficient; SE: standard error.
