Amino Acid Signatures to Evaluate the Beneficial Effects of Weight Loss

Table 4

Amino acid and amino acid score profiles during the Weight Loss and Weight Maintenance program.

Profile	Amino acids; and scores	Uncorrected predictive loadings^a
		Weight; loss	Weight maintenance	Whole course
	Asparagine	−0.042	0.190	0.108
	Glutamine	−0.029	0.151	0.089
	Methionine	−0.012	0.170	0.140
	Proline^b	−0.077	0.161	0.050
	Lysine	−0.095	0.144	0.062
	Valine	−0.170	0.160	−0.087
	Alanine	−0.189	0.188	−0.150
	Aspartate	−0.214	0.111	−0.233
	Tyrosine	−0.177	0.201	−0.077
	Phenylalanine	−0.201	0.205	−0.107
	Tryptophan	−0.191	0.132	−0.130
	DM-AA	−0.196	0.189	−0.167
	OB-BMI	−0.210	0.111	−0.231
	β-alanine	−0.049	−0.032	−0.079
	Cysteine	−0.045	0.008	−0.048
	Glycine	0.031	0.045	0.062
	Threonine	−0.041	0.083	0.018
	Glutamate	−0.195	−0.053	−0.271
	Isoleucine/ leucine	−0.157	0.046	−0.191
	WLWM-WC	−0.208	0.048	−0.247
	WLWM-BMI	−0.198	0.062	−0.229
	OB-WC	−0.216	0.072	−0.253
	Serine	−0.229	0.063	−0.279

^aLoadings obtained from multivariate data analysis and values in bold face indicate a significant change. ^bThe profile for proline is not significance since the increase over the whole course is not significance. The profile for each metabolite describes the change in metabolite levels between the three time points: baseline, after weight loss and after weight maintenance. Each time point is represented by a dot.