Etiology of Hypopituitarism in Adult Patients: The Experience of a Single Center Database in the Serbian Population
Table 1
Etiology of hypopituitarism in all enrolled patients ().
No.
%
Congenital hypopituitarism
74
(14.6)
Head trauma
Trauma brain injury
20
(4.0)
Subarachnoid hemorrhage
7
(1.4)
Extrapituitary cranial irradiation
18
(3.5)
Pituitary tumors
Acromegaly and gigantism
37
(7.2)
Prolactinomas
36
(7.0)
Nonfunctional pituitary tumors
205
(40.5)
Cushing’s disease
10
(2.0)
Pituitary cyst
9
(1.8)
Tumors of sellar region
Craniopharyngioma
30
(5.9)
Germinoma
7
(1.4)
Meningioma, chondroma, granulosa cell tumor
4
(0.8)
Metastasis
2
(0.4)
Infections
Viral
18
(3.5)
Tuberculosis
1
(0.2)
Fungal
2
(0.4)
Vascular disorders
Sheehan’s syndrome
6
(1.2)
Pituitary apoplexy
2
(0.4)
Aneurysm
3
(0.6)
Inflammations/infiltrations
Lymphocytic hypophysitis
8
(1.6)
Histiocytosis X
3
(0.6)
Empty sella
6
(1.2)
Other
•CHARGE Sy, ••Leukodistropy 4H Sy
2
(0.4)
Idiopathic
2
(0.2)
•CHARGE Sy includes coloboma of the eye, heart defects, atresia of the choanae, retardation of growth and/or development, genital abnormalities, and ear abnormalities. ••Leukodystrophy 4H Sy includes hypomyelination, hypogonadotropic hypogonadism, and dental developmental anomalies.
