Research Article
Metabolomic Signature of Coronary Artery Disease in Type 2 Diabetes Mellitus
Table 1
Characteristics in patients with T2D under antidiabetic therapy (stratified by CAD status; CAD = cases, non-CAD = controls).
| | Characteristic | CAD
| Non-CAD
| valuea |
| | Age (years) | 70.0 ± 9.9 | 55.1 ± 13.2 | 1.01E-04 | | Males/females (n/n) | 20/6 | 18/13 | | | BMI (kg/m2) | 31.4 ± 4.3 | 36.3 ± 8.7 | 0.054 | | Diabetes duration (years) | 18.0 ± 12.7 | 11.5 ± 7.6 | 0.065 | | HbA1c (%) | 7.81 ± 1.20 | 8.85 ± 1.80 | 0.156 | | Proinsulin (pmol/l) | 14.7 ± 19.2 | 13.3 ± 7.4 | 0.146 | | C-peptide (pmol/l) | 1519.2 ± 1202.9 | 1473.5 ± 939.0 | 0.654 | | SBP (mmHg) | 129.5 ± 13.2 | 129.4 ± 13.8 | 0.949 | | DBP (mmHg) | 70.5 ± 12.6 | 77.4 ± 10.4 | 0.013 | | TG (mg/dl) | 215.2 ± 156.3 | 205.8 ± 141.2 | 0.423 | | Total cholesterol (mg/dl) | 167.5 ± 39.4 | 189.1 ± 35.5 | 5.84E-03 | | HDL cholesterol (mg/dl) | 38.6 ± 8.9 | 45.7 ± 24.8 | 0.251 | | LDL cholesterol (mg/dl) | 95.1 ± 27.3 | 111.3 ± 35.7 | 0.018 | | Albumin (mg/l) | 16.4 ± 36.6 | 25.9 ± 39.1 | 0.082 | | Creatinine (mg/dl) | 1.33 ± 0.52 | 1.07 ± 0.50 | 0.012 | | Urea (mg/dl) | 61.6 ± 42.5 | 42.9 ± 18.8 | 0.037 | | GFR (ml/min) | 60.4 ± 23.2 | 79.8 ± 29.5 | 9.21E-03 | | Creatine kinase (U/l) | 128.8 ± 79.3 | 174.4 ± 172.7 | 0.642 | | CRP (mg/dl) | 1.51 ± 2.66 | 2.12 ± 4.84 | 0.438 | | Lp(a) (mg/dl) | 22.8 ± 31.8 | 40.0 ± 51.7 | 0.494 | | BNP (pg/ml) | 136.5 ± 178.5 | 30.9 ± 30.6 | 4.68E-06 |
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Data shown as mean ± SD.
a value for comparing patients with CAD and without CAD using Mann-Whitney U test.
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