|
| Subclinical hypothyroidism and CHD | Summary relative risk (95% CI)+ | Studies, n |
|
| Eligible study model | | |
| Random effects | 1.17 (0.91–1.52) | 10 |
| Fixed effects | 1.14 (1.04–1.25) | 10 |
| Stratified by mean age, y | | |
| <65 | 1.54 (1.00–2.39) | 4 |
| ≥65 | 0.96 (0.84–1.10) | 6 |
| <60 | 1.54 (1.00–2.39) | 4 |
| 60–79.9 | 0.96 (0.84–1.09) | 5 |
| ≥80 | 1.18 (0.59–2.36) | 1 |
| Stratified by TSH, mIU/L | | |
| 4.5–9.9 | 1.07 (0.67–1.70) | 4 |
| 10–19.9 | 1.38 (0.68–2.78) | 4 |
| 4.5-6.9 | 0.99 (0.84–1.17) | 2 |
| 7.0–9.9 | 0.92 (0.66–1.27) | 2 |
| Adjustments | | |
| Adjusted analyses or matching | 1.17 (0.91–1.52) | 10 |
| Adjusted for cardiovascular risk factors | 1.09 (0.71–1.65) | 6 |
| Excluding studies | | |
| Exclusion of studies with thyroid hormone recipients | 1.02 (0.92–1.14) | 7 |
| Exclusion of studies with particular population [42] | 1.17 (0.89–1.54) | 9 |
|
| Subclinical hypothyroidism and total mortality | Summary relative risk (95% CI)+ | Studies, n |
|
| Eligible study model | | |
| Random effects | 1.02 (0.93–1.13) | 11 |
| Fixed effects | 1.03 (0.95–1.11) | 11 |
| Stratified by mean age, y | | |
| <65 | 1.16 (0.96–1.40) | 2 |
| ≥65 | 0.98 (0.87–1.10) | 9 |
| <60 | 1.16 (0.96–1.40) | 2 |
| 60–79.9 | 1.02 (0.94–1.11) | 8 |
| ≥80 | 0.52 (0.25–1.08) | 1 |
| Stratified by TSH, mIU/L | | |
| 4.5–9.9 | 1.05 (0.80–1.36) | 2 |
| 10–19.9 | 1.25 (0.67–2.36) | 2 |
| 4.5-6.9 | 0.92 (0.62–1.35) | 1 |
| 7.0–9.9 | 1.06 (0.55–2.04) | 1 |
| Adjustments | | |
| Adjusted analyses or matching | 1.02 (0.93–1.13) | 11 |
| Adjusted for cardiovascular risk factors | 1.06 (0.97–1.15) | 5 |
| Excluding studies | | |
| Exclusion of studies with thyroid hormone recipients | 1.01 (0.90–1.15) | 8 |
| Exclusion of studies with particular population [42] | 1.04 (0.97–1.13) | 10 |
|
| Subclinical hypothyroidism and cardiovascular mortality | Summary relative risk (95% CI)+ | Studies, n |
|
| Eligible study model | | |
| Random effects | 1.06 (0.77–1.45) | 8 |
| Fixed effects | 1.13 (0.98–1.30) | 8 |
| Stratified by mean age, y | | |
| <65 | 2.14 (1.43–3.22) | 1 |
| ≥65 | 1.00 (0.79–1.26) | 7 |
| <60 | 2.14 (1.43–3.22) | 1 |
| 60–79.9 | 1.08 (0.90–1.29) | 6 |
| ≥80 | 0.42 (0.11–1.63) | 1 |
| Stratified by TSH, mIU/L | | |
| 4.5–9.9 | 1.03 (0.73–1.45) | 3 |
| 10–19.9 | 1.25 (0.81–1.95) | 3 |
| 4.5-6.9 | 0.83 (0.31–2.21) | 2 |
| 7.0–9.9 | 1.06 (0.73–1.54) | 2 |
| Adjustments | | |
| Adjusted analyses or matching | 1.06 (0.77–1.45) | 8 |
| Adjusted for cardiovascular risk factors | 1.02(0.52–2.00) | 4 |
| Excluding studies | | |
| Exclusion of studies with thyroid hormone recipients | 0.86 (0.56–1.32) | 4 |
| Exclusion of studies with particular population [42] | 1.11 (0.81–1.52) | 7 |
|
