Relationship between Subclinical Thyroid Dysfunction and the Risk of Cardiovascular Outcomes: A Systematic Review and Meta-Analysis of Prospective Cohort Studies
Table 4
Stratified and sensitivity analysis of the subclinical thyroid dysfunction.
Subclinical hypothyroidism and CHD mortality
Summary relative risk (95% CI)+
Studies, n
Eligible study model
Random effects
1.37 (1.03–1.84)
6
Fixed effects
1.47 (1.22–1.77)
6
Stratified by mean age, y
<65
1.54 (1.11–2.15)
3
≥65
0.98 (0.60–1.62)
3
<60
1.54 (1.11–2.15)
3
60–79.9
1.00 (0.57–1.74)
2
≥80
0.93 (0.30–2.86)
1
Adjustments
Adjusted analyses or matching
1.37 (1.03–1.84)
6
Adjusted for cardiovascular risk factors
1.18 (0.83–1.67)
2
Excluding studies
Exclusion of studies with thyroid hormone recipients
1.17 (0.89–1.53)
5
Exclusion of studies with particular population [42]
1.40 (1.03–1.91)
5
Subclinical hyperthyroidism and CHD mortality
Summary relative risk (95% CI)+
Studies, n
Eligible study model
Random effects
1.45 (1.12–1.86)
6
Fixed effects
1.42 (1.11–1.83)
6
Stratified by mean age, y
<65
1.49 (1.12–1.98)
3
≥65
1.30 (0.75–2.25)
3
<60
1.49 (1.12–1.98)
3
60–79.9
1.40 (0.79–2.49)
2
≥80
0.55 (0.08–3.77)
1
Adjustments
Adjusted analyses or matching
1.45 (1.12–1.86)
6
Adjusted for cardiovascular risk factors
1.52 (1.06–2.18)
3
Excluding studies
Exclusion of studies with thyroid hormone recipients
1.41 (1.05–1.89)
5
Exclusion of studies with particular population [42]
1.47 (1.14–1.90)
5
+Relative risk from meta-analysis using random-effects model.
