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International Journal of Endocrinology
Volume 2017, Article ID 8234502, 7 pages
Research Article

Melatonin in Tuberous Sclerosis Complex Analysis Using Modern Mathematical Modeling Methods

1Department of Pediatric Neurology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland
2Department of Medical Physics, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

Correspondence should be addressed to Justyna Paprocka; lp.airetni@akcorpap.anytsuj

Received 30 August 2016; Revised 23 January 2017; Accepted 9 March 2017; Published 26 April 2017

Academic Editor: Darío Acuña-Castroviejo

Copyright © 2017 Justyna Paprocka et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Purpose. The aim of the study was to assess melatonin secretion pattern in children with TSC and to compare it with the secretion patterns in children with and without epilepsy. Material and Methods. Melatonin secretion was measured every three hours using the RIA method in four children with recognized TSC. The parameters of the melatonin secretion models were interpreted and compared with those obtained for the patients with epilepsy () and the children from the control, nonepileptic group (). To describe the diurnal melatonin secretion, mathematical model was constructed and nonlinear least squares method with the Levenberg-Marquardt optimization algorithm was applied to approximate its parameters. The dim light melatonin onset (DLMO) parameters were also estimated from the model. Results and Conclusions. Statistically significant differences were found between the TSC melatonin secretion profiles and the nonepileptic control group. The profiles for the epileptic and TSC groups were found to be similar. For the TSC group, though a small one, the variations in the MLT release amplitudes seem to be independent of the total number of seizures; however, the MLT release shift appears to depend on the number of seizures.