BMI Modulates the Effect of Thyroid Hormone on Lipid Profile in Euthyroid Adults

Table 3

The association between lipids profile and thyroid parameters in different BMI subgroups.

FT3						FT4				TSH
	BMI < 25		BMI ≥ 25		interaction	BMI < 2		BMI ≥ 25		interaction	BMI< 25		BMI ≥ 25		interaction
	β ± SE		β ± SE			β ± SE		β ± SE			β ± SE		β ± SE
TG	0.145 ± 0.071	0.041	0.076 ± 0.187	0.687	0.687	−0.071 ± 0.022	0.002	−0.113 ± 0.069	0.101	0.023	0.078 ± 0.045	0.085	0.245 ± 0.125	0.051	0.138
CHOL	0.172 ± 0.061	0.005	0.205 ± 0.070	0.004	0.171	0.004 ± 0.020	0.822	0.005 ± 0.026	0.840	0.769	0.110 ± 0.039	0.005	0.068 ± 0.047	0.149	0.193
HDL-C	0.010 ± 0.020	0.613	0.041 ± 0.022	0.058	0.040	0.017 ± 0.006	0.010	0.010 ± 0.008	0.220	0.258	0.008 ± 0.013	0.548	−0.018 ± 0.014	0.203	0.105
LDL-C	0.158 ± 0.053	0.003	0.177 ± 0.061	0.004	0.054	0.007 ± 0.017	0.695	0.031 ± 0.023	0.177	0.283	0.063 ± 0.033	0.061	0.003 ± 0.041	0.944	0.103

We stratified the study group according to BMI levels: BMI < 25 kg/m²: normal-weight group; BMI ≥ 25 kg/m²: overweight/obese group. Reported values are betas ± standard error and results from linear regression analysis with lipid parameters as dependent variables and thyroid parameters as independent variables. Betas are scaled and adjusted for age and sex. for interaction results from linear regression analysis with FT3BMI (or FT4BMI, TSHBMI) as independent variable and lipid profile as dependent variables. Significant associations are indicated in bold. was considered statistically significant. , .