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International Journal of Endocrinology
Volume 2017 (2017), Article ID 8724869, 8 pages
Research Article

Serum Osteoprotegerin Is a Potential Biomarker of Insulin Resistance in Chinese Postmenopausal Women with Prediabetes and Type 2 Diabetes

1Department of Endocrinology and Metabolism, Nanchang Key Laboratory of Diabetes, The Third Hospital of Nanchang, No. 2 Xiangshan South Road, Nanchang, Jiangxi 330009, China
2Department of Finance, Nanchang Normal University, No. 889 Ruixiang Road, Nanchang, Jiangxi 330009, China

Correspondence should be addressed to Ping Tu

Received 21 August 2016; Revised 28 October 2016; Accepted 14 November 2016; Published 31 January 2017

Academic Editor: Andre Pascal Kengne

Copyright © 2017 Peng Duan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aim of this study is to investigate the circulating OPG levels in postmenopausal women with diabetes and prediabetes and explore the relationships between serum OPG and insulin resistance. A total of 271 unrelated Chinese postmenopausal women were recruited in this study. The subjects were divided into type 2 diabetes mellitus (T2DM) group (), impaired glucose regulation (IGR) (), and normal glucose regulation group (NGR) (), according to different glucose regulation categories. Serum OPG levels were measured by enzyme-linked immunosorbent assay. The serum OPG concentration in NGR group, 151.00 ± 45.72 pg/mL, was significantly lower than that in IGR group (169.28 ± 64.91 pg/mL) () and T2DM group (183.20 ± 56.53 pg/mL) (), respectively. In multiple linear regression analysis, HOMA-IR, age, 2hPG, AST, ALP, and eGFR were found to be independent predictors of OPG. Increased serum OPG levels (OR = 1.009, ) may be a risk factor for insulin resistance. The present study suggests that OPG might be implicated in the pathogenesis of diabetes and is a potential biomarker of insulin resistance in subjects with diabetes and prediabetes.