Thyroid Imaging Reporting and Data System Score Combined with the New Italian Classification for Thyroid Cytology Improves the Clinical Management of Indeterminate Nodules

Table 2

Association of clinical and ultrasonographic (US) features with histology of 69 nodules with indeterminate cytological diagnosis. CFD, color-flow Doppler.

Clinical and US features	Benign; ()	Malignant; ()	p
Gender
Male	14 (26.29%)	4 (23.52%)	0.527
Female	38 (73.1%)	13 (76.47%)
Age (yr)
Median age	58 (13–77)	50 (20–75)	0.347
Morphology
Taller than wide	7 (13.46%)	6 (35.3%)	0.046
Round/oval shape	45 (86.53%)	11 (64.70%)
Median nodule; volume (ml)	1.2 (0.12–12)	0.44 (0.1–8.6)	0.016
Margin
Irregular	15 (28.8%)	11 (64.70%)	0.008
Regular	37 (71.1%)	6 (35.3%)
Microcalcification
Yes	9 (17.30%)	7 (41.2%)	0.043
No	43 (82.7%)	10 (58.9%)
Echogenicity
Hypoechogen	25 (48.1%)	13 (76.47%)	0.021
Isoechogen	19 (36.5%)	1 (5.88%)
Echostructure
Mixed	8 (15.4%)	3 (17.64%)	0.545
Solid	44 (84.6%)	14 (82.35%)
Color-flow Doppler
CFD 1	11 (21.15%)	5 (29.41%)	0.755
CFD 2	6 (11.5%)	1 (5.88%)
CFD 3	35 (67.30%)	11 (64.70%)
Nodularity
Uninodular	20 (38.5%)	5 (29.41%)	0.356
Multinodular	32 (61.53%)	12 (70.6%)