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International Journal of Endocrinology
Volume 2017, Article ID 9707284, 8 pages
Research Article

Synergistic Effect of Family History of Diabetes and Dietary Habits on the Risk of Type 2 Diabetes in Central China

1Division of Endocrinology, Department of Internal Medicine, The First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China
2Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou 450052, China

Correspondence should be addressed to Guijun Qin; nc.ude.uzz@jgniqyh

Received 30 November 2016; Revised 24 February 2017; Accepted 19 March 2017; Published 13 April 2017

Academic Editor: Andrea Tura

Copyright © 2017 Yanyan Zhao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Family history of diabetes (FHD) and lifestyle are associated with type 2 diabetes (T2DM), but little is known about the FHD diet interactions. We aimed to analyze the interactions of FHD and lifestyle factors in Chinese T2DM onset. Methods. This was a cross-sectional survey in central urban China ( patients with T2DM and non-T2DM subjects). The biological interactions, defined by Rothman interactions, between FHD and each dietary factor were analyzed by using the synergy index (S) scores. Results. After adjustment for age, gender, BMI, and WHR, a uniparental FHD (, 95% CI: 2.36–3.42, ), a paternal history of FHD (, 95% CI: 1.91–3.35, ), a maternal history of FHD (, 95% CI: 2.67–4.02, ), a biparental history of FHD (, 95% CI: 2.98–9.31, ), and a FHD, irrespective of the parent (, 95% CI: 3.08–4.17, ), were associated with T2DM onset. There were significant interactions between FHD and consuming <15 g/d of potatoes (, 95% CI: 1.12–2.12), <8 g/d of poultry (, 95% CI: 1.04–2.17), <85 g/d of fresh fruits (, 95% CI: 1.63–2.88), and no freshly squeezed juice (, 95% CI: 1.46–3.49). Conclusions. Risk of T2DM was synergistically affected by FHD and dietary habits. Nutrition educational intervention may decrease the prevalence of T2DM in the Chinese with FHD.