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International Journal of Endocrinology
Volume 2018 (2018), Article ID 1289485, 10 pages
https://doi.org/10.1155/2018/1289485
Research Article

Different Associations of Trunk and Lower-Body Fat Mass Distribution with Cardiometabolic Risk Factors between Healthy Middle-Aged Men and Women

1Open Research Center for Studying of Lifestyle-Related Diseases, Mukogawa Women’s University, 6-46 Ikebiraki-cho, Nishinomiya, Hyogo 663-8558, Japan
2Department of Endocrinology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, China
3School of Computing, University of South Alabama, Mobile, AL 36688-0002, USA
4Department of Food Sciences and Nutrition, School of Human Environmental Science, Mukogawa Women’s University, 6-46 Ikebiraki-cho, Nishinomiya, Hyogo 663-8558, Japan
5Research Institute for Nutrition Sciences, Mukogawa Women’s University, 6-46 Ikebiraki-cho, Nishinomiya, Hyogo 663-8558, Japan
6Department of Diabetes and Endocrinology, Toho University Omori Medical Center, Omori-Ku, Omori-nishi 6-11-1, Tokyo 143-8541, Japan

Correspondence should be addressed to Bin Wu; moc.qq@umk.nib.uw

Received 19 August 2017; Accepted 30 October 2017; Published 4 February 2018

Academic Editor: Seung-Hwan Lee

Copyright © 2018 Bin Wu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The aim of this study was to assess whether the gender-specific pattern of fat mass (FM) distribution is related to gender differences in cardiometabolic risk factors. 207 healthy middle-aged Japanese were included in the study. We measured FM in the total body, trunk, and lower-body with dual-energy X-ray absorptiometry (DXA). The percentage of trunk FM (TFM) and lower-body FM (LFM) is noted as %TFM and %LFM, respectively. Other measurements included glucose and insulin during oral glucose tolerance test (OGTT), leptin, adiponectin, plasminogen activator inhibitor-1 (PAI-1), tumor necrosis factor-α (TNF-α), C-reactive protein (CRP), and systemic oxidative stress marker. Arterial properties were indicated by cardio-ankle vascular index (CAVI) and intima-media thickness (IMT) of the common carotid artery. The results showed that %TFM is higher whereas %LFM is lower in men than in women and men have a more atherogenic cardiometabolic profile. In both genders, %TFM (%LFM) is related to an unfavorable (favorable) cardiometabolic profile. In particular, the relation between %LFM and OGTT-derived insulin sensitivity index is stronger in women than in men. These findings suggested that in relatively healthy adults, android and gynoid pattern of FM distribution contributes to gender differences in cardiometabolic risk factors.