The Polycystic Ovary Syndrome and the Metabolic Syndrome: A Possible Chronobiotic-Cytoprotective Adjuvant Therapy

Figure 4

Effect of melatonin in PCOS associated with metabolic syndrome. Melatonin normalizes high blood pressure (BP) and circulating indexes of inflammation. It also improves insulin sensitivity and restores disrupted circadian rhythms. Melatonin directly affects ovarian function: it is concentrated in human ovarian follicles in relation to the level in plasma, and it improves granulosa cell steroidogenesis and follicular function in humans (adapted from Reiter et al. [61]).