The Polycystic Ovary Syndrome and the Metabolic Syndrome: A Possible Chronobiotic-Cytoprotective Adjuvant Therapy

Table 1

Relevance of melatonin in PCOS.

Observation	Reference/s
Significantly higher secretion of melatonin in PCOS women	[64–68]
Family association study between melatonin receptor gene polymorphisms and PCOS	[77–79]
Supplementation of in vitro culture medium with melatonin improved IVF outcome in PCOS	[80]
Melatonin and myo-inositol enhanced, synergistically, oocyte, and embryo quality and improved in vitro fertilization of patients with PCOS	[81]
Melatonin treatment restores menstrual cyclicity in women with PCOS	[82]
Treatment of preinvasive endometrial cancer in women with PCOS using female sexual hormones in combination with melatonin, antidiabetic, antidopaminergic, and antiserotonin therapy favorably influenced female sexual hormone profile and lipid metabolism and caused the restoration of normal endometrium	[83]
Melatonin treatment ameliorated oxidative stress and inflammatory parameters of obese women	[84]
Reduced fat mass and increased lean mass in response to 1 year of melatonin treatment in postmenopausal women	[85]
Protective effects of melatonin against metabolic and reproductive disturbances in rodent models of PCOS	[104–107]