International Journal of Endocrinology

Research Article

Copy Number Variation of Immune-Related Genes and Their Association with Iodine in Adults with Autoimmune Thyroid Diseases

Table 3

The distributions of SIRPB1 and TMEM91 CNVs in AITD patients and controls.
Gene/CNVCase, n (%)
N = 158		Control, n (%)
N = 181		 value
SIRPB1   
 Normal138 (87.34)174 (96.13) 
 Loss9 (5.70)6 (3.32)0.288
 Gain11 (6.96)1 (0.55)0.001
TMEM91   
 Normal148 (93.67)176 (97.24) 
 Loss9 (5.70)4 (2.21)0.095
 Gain1 (0.63)1 (0.55)1.000
The frequency of CNV gain for SIRPB1 gene in the case group was significantly higher than that in the control group.