High Expression of Somatostatin Receptors 2A, 3, and 5 in Corticotroph Pituitary Adenoma

Table 3

Expression rates of SSTR1–5 in adenoma samples.

	^1	Mean	95% CI	Negative (%)	C^2	P^2	G^2	N^2
SSTR1	236	2.47	2.15-2.78	65 (28)
Corticotroph	79	1.79	1.34-2.25	23 (29)	—	0.0868	0.2141	0.001
PIT-1 positive	54	2.53	1.90-3.17	16 (30)	0.0868	—	0.9894	0.2089
Gonadotroph	22	2.52	1.32-3.72	6 (27)	0.2141	0.9894	—	0.3509
Nonfunctioning	81	3.07	2.46-3.68	20 (25)	0.001	0.2089	0.3509	—
SSTR2A	226	3.88	3.50-4.27	17 (8)
Corticotroph	80	3.73	3.19-4.26	2 (3)	—	<.0001	0.0217	0.0126
PIT-1 positive	52	6.43	5.50-7.37	2 (4)	<.0001	—	<.0001	<.0001
Gonadotroph	18	2.19	1.31-3.08	3 (17)	0.0217	<.0001	—	0.4462
Nonfunctioning	76	2.70	2.21-3.19	10 (13)	0.0126	<.0001	0.4462	—
SSTR3	232	1.76	1.52-2.01	87 (38)
Corticotroph	79	2.91	2.42-3.39	9 (11)	—	<.0001	0.0280	<.0001
PIT-1 positive	54	0.51	0.27-0.75	39 (72)	<.0001	—	0.0011	0.0026
Gonadotroph	20	1.98	1.23-2.73	5 (25)	0.0280	0.0011	—	0.1908
Nonfunctioning	78	1.42	1.06-1.78	34 (44)	<.0001	0.0026	0.1908	—
SSTR4	235	1.34	1.15-1.53	93 (40)
Corticotroph	81	0.90	0.64-1.15	43 (53)	—	0.0238	0.0341	0.0013
PIT-1 positive	54	1.44	0.97-1.91	23 (43)	0.0238	—	0.5937	0.4281
Gonadotroph	22	1.64	1.02-2.25	6 (27)	0.0341	0.5937	—	0.9822
Nonfunctioning	78	1.64	1.31-1.98	21 (27)	0.0013	0.4281	0.9822	—
SSTR5	233	4.08	3.53-4.63	70 (30)
Corticotroph	82	7.11	6.11-8.12	9 (11)	—	0.0003	<.0001	<.0001
PIT-1 positive	52	4.96	3.96-5.97	9 (17)	0.0003	—	<.0001	<.0001
Gonadotroph	21	0.90	0.50-1.31	12 (57)	<.0001	<.0001	—	0.7572
Nonfunctioning	78	1.16	0.83-1.49	41 (53)	<.0001	<.0001	0.7572	—

¹The varying number of analyzed cases is based on the vertical heterogeneity of the tumor cylinders and in adequate fixation or staining of the samples in a few single cases. ²Corticotroph (C), PIT-1 positive (P), gonadotroph (G), and nonfunctioning (N) pituitary adenoma.