Melatonin Treatment Improves Insulin Resistance and Pigmentation in Obese Patients with Acanthosis Nigricans

Table 1

Effects of melatonin on various biochemical indices.

Parameters	Baseline	After 12 weeks of treatment	value
HOMA-IR	8.99 ± 5.1047	7.77 ± 5.2169	0.027
Matsuda index	2.822 ± 1.5423	3.744 ± 2.0238	0.017
FPG, mmol/l	5.365 ± 0.8645	5.341 ± 0.8307	0.839
Glucose 30, mmol/l	9.853 ± 1.9872	9.259 ± 1.8416	0.044
Glucose 60, mmol/l	10.794 ± 2.8203	10.247 ± 2.7405	0.156
Glucose 120, mmol/l	8.341 ± 3.1071	8.071 ± 3.2299	0.340
Glucose 180, mmol/l	5.835 ± 2.4392	5.812 ± 1.6605	0.939
Fasting insulin, μU/ml	37.0935 ± 20.26215	32.1018 ± 20.29752	0.010
Insulin 30, μU/ml	149.8935 ± 54.80039	116.8088 ± 54.59683	<0.01
Insulin 60, μU/ml	170.45 ± 83.12034	143.9794 ± 63.21096	0.006
Insulin 120, μU/ml	160.4506 ± 85.95451	135.0529 ± 92.32970	0.018
Insulin180, μU/ml	80.2476 ± 64.86455	73.1259 ± 67.18857	0.416
Fasting CP, ng/ml	4.8776 ± 1.5665	4.5759 ± 1.4895	0.130
TC, mmol/l	4.9312 ± 0.7684	4.7671 ± 0.7834	0.212
TG, mmol/l	1.9094 ± 0.7576	1.7824 ± 0.8641	0.338
HDL-C, mmol/l	1.1029 ± 0.2911	1.0741 ± 0.2430	0.422
LDL-C, mmol/l	3.0282 ± 0.6262	2.9218 ± 0.4897	0.221
FFA, mmol/l	0.588 ± 0.2233	0.506 ± 0.1600	0.084
UA, μmol/l	443.518 ± 132.5464	432.635 ± 111.2079	0.400
CRP, mg/l	4.6159 ± 3.27755	3.6429 ± 2.89784	0.014
IL-6, pg/ml	15.3318 ± 13.84451	13.8276 ± 10.09683	0.527
IL-8, pg/ml	221.1482 ± 321.43527	177.6976 ± 241.08857	0.328
TNF-α, pg/ml	28.0594 ± 25.81318	16.9288 ± 14.92093	0.040
SOD, U/ml	154.06 ± 15.262	173.35 ± 55.623	0.166
ALT, U/l	47.224 ± 23.7542	42.929 ± 25.7068	0.391
AST, U/l	32.400 ± 16.5831	30.918 ± 13.5636	0.625
Tbil, μmol/l	10.376 ± 5.3582	10.476 ± 5.2538	0.903
ALP, U/l	77.347 ± 38.9236	73.018 ± 37.5913	0.217
Cr, μmol/l	59.641 ± 14.6798	60.959 ± 14.6248	0.312
UN, mmol/l	4.647 ± 1.1906	4.924 ± 1.3796	0.118
fT3, pmol/l	5.1976 ± 0.50209	5.0829 ± 0.55324	0.203
fT4, pmol/l	15.3112 ± 1.32976	15.0959 ± 1.85283	0.515
TSH, pmol/l	2.75288 ± 1.389337	2.43759 ± 1.174457	0.092

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