The Potential Role of miRNAs as New Biomarkers for Osteoporosis

Table 3

miRNA dysregulated in plasma of osteoporotic patients and their function.

miRNA	Expression	Function	Target	Reference
miR-21	Downregulated	miR-21 promotes OB differentiation and mineralization	Smad7	[43]
miR-21		Essential for OC formation and OC bone-resorbing activity, preserves OCs from apoptosis	FasL, PDCD4	[42]
miR-31	Upregulated	Promotes OC formation and activity by promoting the formation of the peripheral acting ring	RhoA	[54]
miR-133a	Upregulated	Downregulated during OB differentiation, it is a suppressor of osteogenesis	Runx2	[57]
miR-148a	Upregulated	Promotes OC genesis and increased the bone resorption area on dentin slices	MAFB	[45]