Smooth Muscle-Specific BCL6+/− Knockout Abrogates Sex Bias in Chronic Hypoxia-Induced Pulmonary Arterial Hypertension in Mice

Figure 3

Reduced BCL6 expression in pulmonary arterial (PA) segments in SMC:STAT5a/b−/− male and female mice in normoxia and hypoxia. (a) Representative immunofluorescence images for expression of BCL6 in PA segments in lungs of Wt and SMC:STAT5a/b−/− male and female mice (arrows) kept for 4 weeks in normoxia or hypoxia. The lung sections used for this experiment derive from the mouse experiment reported in Figure 4 in [19]. Scale bar = 20 μm. (b) Quantitation of BCL6 expression in PA segments as illustrated in (a) expressed as a ratio of fluorescence in PA segments compared to that in the adjacent bronchial epithelium in the same section. n = the number of arterial segments quantitated per group; by ANOVA.

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