The Renin-Angiotensin-Aldosterone System as a Therapeutic Target in Late Injury Caused by Ischemia-Reperfusion

Figure 3

Aldosterone synthesis. The process starts with the activation of the AT₁R; the G protein is uncoupled and segmented in two fragments. The subunit alpha will activate the phospholipase C which will be produced from PIP₂, DAG, and IP₃; the DAG will activate the PKC, and then this will phosphorylate the P450 complex, the hormone-sensitive lipase, and the StAR family of cholesterol transporters, which will lead to the production of aldosterone.