Review Article
Adipokines in Semen: Physiopathology and Effects on Spermatozoas
Table 1
Consequences on male fertility phenotypes of animal models with missing adipokine or adipokine receptor.
| Type | Phenotype | References |
| ob/ob mice | Testicular atrophy Decrease nuclear volume of Sertoli cells, spermatogonia, and spermatocytes | [40] | ob/ob mice | Infertile Reduction of testis weight, multinucleated spermatids, few spermatozoa, and anormal Leydig cells | [41] | db/db mice | Infertile | [43] | db/db mice | Infertile Impairment of spermatogenesis and sperm motility | [14] | fa/fa rat (Zucker rat) | Alteration in sperm production and sperm DNA damage | [45] | AdipoR2 | Seminiferous tubular atrophy with aspermia and reduced testicular weight | [54] | AdipoR2 | Decrease of testis weight | [58] |
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