International Journal of Endocrinology / 2018 / Article / Tab 1

Review Article

Adipokines in Semen: Physiopathology and Effects on Spermatozoas

Table 1

Consequences on male fertility phenotypes of animal models with missing adipokine or adipokine receptor.


ob/ob miceTesticular atrophy
Decrease nuclear volume of Sertoli cells, spermatogonia, and spermatocytes
ob/ob miceInfertile
Reduction of testis weight, multinucleated spermatids, few spermatozoa, and anormal Leydig cells
db/db miceInfertile[43]
db/db miceInfertile
Impairment of spermatogenesis and sperm motility
fa/fa rat (Zucker rat)Alteration in sperm production and sperm DNA damage[45]
AdipoR2Seminiferous tubular atrophy with aspermia and reduced testicular weight[54]
AdipoR2Decrease of testis weight[58]

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