Malignancy Risk and Related Factors of Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance in Thyroid Fine Needle Aspiration

Table 4

Logistic regression analysis of predictors of malignancy in histologically confirmed thyroid nodules after initially being diagnosed as AUS/FLUS.

	Age-adjusted OR (95% CI)	value	Multivariate-adjusted OR (95% CI)	value
Size	0.90 (0.86–0.95)	<0.01	0.96 (0.91–1.02)	0.20
Hyper- or isoechoic versus hypo- or anechoic	18.81 (5.89–60.04)	<0.01	9.31 (1.89–45.9)	<0.01
Round to oval versus irregular shape	2.42 (0.64–9.10)	0.19	0.79 (0.09–6.88)	0.87
No calcification versus calcification	0.76 (0.29–1.97)	0.58	0.56 (0.15–2.07)	0.38
Smooth versus irregular margin	0.00	0.99	0.00	0.99
Parallel versus nonparallel	783,560,819 (?)	0.99	197,355,593(?)	0.99

Adjusted for age, size (as a continuous variable), and all the other variables listed in the table. AUS/FLUS: atypia of undetermined significance/follicular lesion of undetermined significance.