Osteoporosis Is Associated with Deteriorating Clinical Status in Adults with Cystic Fibrosis

Table 1

Baseline characteristics.

	Overall
ppFEV1 (SD)	67 ± 23
BMI kg/m^2 (SD)	22.3 ± 3.5
Age, years (SD)	33.1 ± 10
Males, n (%)	62 (50.4)
Females, n (%)	63 (49.6)
Pancreas insufficiency, n (%)	120 (97)
Homozygous F508del, n (%)	89 (71)
CF-related diabetes, n (%)	51 (41)
CF-related diabetes, duration in years (IQR)	10 (6–18)
Chronic infection, n (%)	101 (81)
Steroid inhalation therapy, n (%)	55 (44)
Additional D3 supplementation, n (%)	47 (38)
Proton pump inhibitors, n (%)	44 (35)
Spine BMD	1.145 ± 0.158
Femoral BMD	0.974 ± 0.197
T score	−0.981 ± 1.260
Z score	−0.748 ± 1.110

ppFEV1: percent predicted forced expiratory volume in 1 second; BMI: body mass index; extra D₃ supplementation: additional D₃ supplementation on top of routine supplementation; BMD: bone mineral density; T score: lowest T score at any site for cases; Z score: lowest Z score at any site for cases; IQR: interquartile range; SD: standard deviation.