Research Article
Osteoporosis Is Associated with Deteriorating Clinical Status in Adults with Cystic Fibrosis
Table 2
Calcium metabolic and biochemical differences between groups.
| | Normal range | Overall | BMD within the normal range | Osteoporosis | p between groups |
| | 25OHD () | (>50 nmol/l) | 49 (32–71) | 49 (34–71) | 32 (16–71) | 0.39 | | Calcium () | (2.15–2.51 mmol/l) | 2.21 (2.12–2.31) | 2.22 (2.13–2.32) | 2.12 (2.02–2.28) | 0.26 | | PTH () | (1.6–6.9 pmol/l) | 2.12 (1.36–2.91) | 2.12 (1.37–2.76) | 2.13 (1.6–4.86) | 0.18 | | Mg2+ () | (0.71–0.94 mmol/l) | 0.8 (0.75–0.84) | 0.8 (0.76–0.84) | 0.77 (0.7–0.87) | 0.18 | | PH− () | (0.71–1.53 mmol/l) | 1.07 (0.96–1.18) | 1.07 (0.96–1.16) | 1.11 (0.94–1.29) | 0.44 | | A phosphatase () | (35–105 U/l) | 94 (77–122) | 89 (76–120) | 112 (83–170) | 0.11 | | Zink () | (10–19 μmol/l) | 13 (11–14) | 13 (11–15) | 11 (9–13) | 0.13 | | Albumin () | (36–48 g/l) | 38 (34–42) | 39 (34–42) | 37 (30–39) | 0.02 | | IgG () | (6.1–14.9 g/l) | 11.2 (9–13.7) | 11.2 (9.00–13.25) | 12.00 (8.4–14.90) | 0.46 | | hsCRP () | (<3.00 mg/l) | 2.34 (1.00–6.97) | 2.10 (0.93–6.94) | 4.52 (2.80–8.22) | 0.04 | | Urea () | (3.2–8.1 mmol/l) | 4.7 (3.93–6.18) | 4.70 (3.90–6.10) | 5.00 (4.20–6.80) | 0.84 | | Creatinine () | (60–105 μmol/l) | 70 (60–83) | 69 (60–81) | 73 (63–104) | 0.13 | | ALT () | (10–70 U/l) | 26 (19–39) | 26 (19–42) | 28 (19–31) | 0.02 | | LDH () | (115–255 U/l) | 158 (142–176) | 159 (142–179) | 152 (140–170) | 0.43 | | hbA1c () | (<48 mmol/mol) | 41 (36–53) | 40 (36–49) | 55 (40–78) | 0.007 | | TSH () | (0.65–4.80 × 10−3 IU/l) | 1.85 (1.24–2.58) | 1.87 (1.25–2.61) | 1.81 (0.92–2.56) | 0.90 |
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All data presented as median and interquartile range (IQR). 25OHD: vitamin D; PTH: parathyroid hormone; Mg2+: magnesium; PH−: phosphate; A phosphatase: alkaline phosphatase; IgG: immunoglobulin G; hsCRP: high-sensitive C-reactive protein; ALT: alanine aminotransferase; LDH: lactate dehydrogenase; hbA1c: hemoglobin A1c; TSH: thyroid-stimulating hormone; m: milli; μ: micro; n: nano; pmol: picomol; l: liter; IU: international units; g: gram.
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