International Journal of Endocrinology / 2018 / Article / Tab 5

Research Article

Osteoporosis Is Associated with Deteriorating Clinical Status in Adults with Cystic Fibrosis

Table 5

Difference in baseline characteristics between osteoporotic and nonosteoporotic groups.

BMD within the normal range
()
Osteoporosis
()
p between groups

ppFEV1 (IQR)70 (52–87)44 (27–65)<0.001
BMI kg/m2 (IQR)22.5 (20.4–24.5)19.6 (18.8–20.7)<0.001
Age, years (IQR)30 (24–39)34 (25–47)0.52
Males, n (%)55 (52)7 (37)0.27
Females, n (%)51 (48)12 (63)
Pancreas insufficiency, n (%)101 (95)19 (100)ns
Homozygous F508del, n (%)74 (70)16 (84)0.38
CF-related diabetes, n (%)43 (39)8 (53)0.03
CF-related diabetes, duration in years (IQR)9 (6–16)15 (10–25)0.06
Chronic infection, n (%)82 (77)19 (100)0.02
Steroid inhalation therapy, n (%)52 (47)3 (20)0.06
Additional D3 supplementation, n (%)36 (34)11 (58)0.05
Proton pump inhibitors, n (%)41 (39)2 (16)0.07

ppFEV1: percent predicted forced expiratory volume in 1 second; BMI: body mass index; additional D3 supplementation: additional D3 supplementation in addition to routine supplementation; BMD: bone mineral density; IQR: interquartile range.