Clinical Characteristics of Aldosterone- and Cortisol-Coproducing Adrenal Adenoma in Primary Aldosteronism
Table 2
Baseline biochemical and hormonal parameters of A/CPA and pure APA patients.
A/CPA patients
Pure APA patients
value
Hypokalemia (%)
90.91%
89.66%
1.000
Serum potassium (mmol/L)
2.537 ± 0.154
2.475 ± 0.560
0.9683
Plasma aldosterone (ng/dL)
23.49 ± 14.20
24.23 ± 6.986
0.2213
ARR
151.6 ± 146.3
139.1 ± 112.3
0.9664
Saline infusion test: aldosterone (ng/dL)
16.079 ± 4.310
21.845 ± 6.773
0.1397
Basal cortisol 8:00 am (nmol/L)
391.5 ± 135.6
343.6 ± 131.8
0.2033
ACTH 8:00 am (pmol/L)
5.974 ± 4.695
5.015 ± 2.781
0.9222
UFC/24 h (nmol/day)
455.6 ± 288.5
302.4 ± 204.7
0.1858
Cortisol after 1 mg dexamethasone test (nmol/L)
119.5 ± 76.26
37.05 ± 10.024
0.0098
Cortisol after low-dose dexamethasone (nmol/L)
235.8 ± 234.3
—
—
Cortisol after high-dose dexamethasone (nmol/L)
116.5 ± 24.47
—
—
ARR: aldosterone-to-plasma renin activity ratio; ACTH: adrenocorticotropic hormone; UFC: urinary free cortisol; the lowest cortisol value that can be detected in our laboratory is 25.7 nmol/L. Thus, the results of a fraction of pure APA patients who underwent the 1 mg dexamethasone test could not be used in this analysis due do cortisol levels < 25.7 mmol/L. .
