Vanadyl Sulfate Effects on Systemic Profiles of Metabolic Syndrome in Old Rats with Fructose-Induced Obesity

Figure 4

Effect of VS on serum glucose and insulin levels in old obese male Wistar rats. After obesity induced with high-fructose diet (HFD) during 28 weeks, insulin sensitizers treatment (metformin (MET) or VS) was applied from week 32 to week 40, using saline solution (SS) as a control. (a) Postprandial blood glucose levels in rats after 32 weeks on ND or HFD (pretreatment bars) and after 8 weeks of insulin sensitizer treatment (posttreatment bars). comparing ND + VS pre-treatment versus ND + VS post-treatment. comparing HFD + VS post-treatment versus HFD plus SS or MET post-treatment. (b) Postprandial blood insulin levels in rats after 32 weeks on ND or HFD (pretreatment bars) and after 8 weeks of insulin sensitizer treatment (post-treatment bars). comparing pre-treatment versus post-treatment. (c) Homeostatic model assessment for insulin resistance (HOMA-IR) in rats after 32 weeks on ND or HFD (pretreatment bars) and after 8 weeks of insulin sensitizer treatment (posttreatment bars). HFD + MET pre-treatment versus HFD + SS post-treatment. HFD + VS post-treatment versus HFD + VS pre-treatment HFD + SS or HFD + MET post-treatment. Data are ().

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