Research Article
Hepatic Steatosis Index in Acromegaly: Correlation with Insulin Resistance Regardless of the Disease Control
Table 1
Clinical and biochemical features of patients at diagnosis and after 12 months of treatment.
| | Baseline | After 12 months | | | Subjects (%) | Subjects (%) |
| | Gender | | | | | Males | 17 (55) | — | — | | Females | 14 (45) | | | | | | | | | Age (years) | | — | — | | Duration of disease (years) | | — | | | Fasting GH (μg/L) | | | 0.033 | | IGF-1 ULN | | | <0.001 | | BMI (kg/m2) | | | 0.974 | | WC (cm) | | | 0.885 | | Systolic blood pressure (mmHg) | | | 0.330 | | Diastolic blood pressure (mmHg) | | | 0.224 | | Fasting glucose (mmol/L) | | | 0.646 | | Fasting insulin (IU/mL) | | | 0.014 | | HOMA-IR | | | 0.002 | | ISI Matsuda | | | <0.001 | | Total cholesterol (mmol/L) | | | 0.133 | | HDL cholesterol (mmol/L) | | | 0.269 | | LDL cholesterol (mmol/L) | | | 0.326 | | Triglycerides (mmol/L) | | | 0.146 | | AST (IU/L) | | | 0.970 | | ALT (IU/L) | | | 0.473 | | GGT (IU/L) | | | 0.371 | | ALP (IU/L) | | | 0.425 | | Total bilirubin (μmol/L) | | | 0.964 | | HSI | | | <0.001 | | Hepatic steatosis (ultrasound) | 19 (61.2) | 19 (61.2) | — | | 26 (83.8) | 14 (45.1) | <0.001 |
|
|
IFG: impaired fasting glucose; IGT: impaired glucose tolerance; WC: waist circumference; AST: aspartate transaminase; ALT: alanine transaminase; GGT: γ-Glutamyltransferase; ALP: alkaline phosphatase; HSI: hepatic steatosis index.
|
