SLC6A4 5HTTLPR Polymorphism Affects Insulin Secretion in Patients with Polycystic Ovary Syndrome
Table 1
Genotype frequencies in healthy controls and PCOS patients.
Polymorphism
Healthy controls
PCOS patients
Genotype
Number (%)
MAF
pHWE
Genotype
Number (%)
MAF
pHWE
5HTR1A rs6295a
CC
13 (14.6)
0.54
0.020
CC
21 (33.3)
0.47
0.107
CG
55 (61.8)
CG
25 (39.7)
GG
21 (23.6)
GG
17 (27.0)
5HTR1B rs13212041b
TT
51 (57.3)
0.24
0.574
TT
39 (63.9)
0.25
0.001
TC
34 (38.2)
TC
13 (21.3)
CC
4 (4.5)
CC
9 (14.8)
5HTTLPRc
LL
22 (26.2)
0.45
0.160
LL
19 (34.5)
0.37
0.128
LS
48 (57.1)
LS
31 (56.4)
SS
14 (16.7)
SS
5 (9.1)
aData for 5 healthy controls and 2 patients are missing. bData for 5 healthy controls and 4 patients are missing. cData for 10 healthy controls and 10 patients are missing. MAF: minor allele frequency.
