Research Article
SLC6A4 5HTTLPR Polymorphism Affects Insulin Secretion in Patients with Polycystic Ovary Syndrome
Table 2
Serotonin system polymorphisms and blood glucose levels during OGTT.
| | Polymorphism | Genotype | Fasting blood glucose (mmol/L) | Glucose 30 min (mmol/L) | Glucose 60 min (mmol/L) | Glucose 90 min (mmol/L) | Glucose 120 min (mmol/L) | AUC | | Median (25%–75%) | | Median (25%–75%) | | Median (25%–75%) | | Median (25%–75%) | | Median (25%–75%) | | Median (25%–75%) | |
| | 5HTR1A rs6295 | CC | 5.25 (4.83–5.68) | 0.530 | 9.3 (7.73–10.25) | 0.328 | 9.4 (7.68–10.63) | 0.287 | 8.85 (7.35–9.68) | 0.192 | 7.7 (5.7–8.68) | 0.277 | 16.76 (15.17–18.48) | 0.182 | | CG + GG | 5.1 (4.7–5.5) | 8.4 (7.45–9.6) | 8.65 (7.08 11.1) | 7.9 (6.55–9.33) | 6.9 (5.8–7.93) | 15.66 (13.64–18.09) | | 5HTR1B rs13212041 | TT | 5.2 (4.8–5.6) | 0.456 | 8,8 (7.45–9.6) | 0.647 | 9 (7.35–10.23) | 0.568 | 8.55 (6.68–9.53) | 0.518 | 7.35 (6.35–8.53) | 0.105 | 16.39 (13.98–17.96) | 0.485 | | TC + CC | 5.05 (4.6–5.5) | 9 (7.35–10.23) | 9 (7.55–10.03) | 7.75 (6.53–9.53) | 6.95 (5.4–7.48) | 15.36 (13.63–18.61) | | 5-HTTLPR | LL | 5.3 (4.9–5.7) | 0.334 | 8.9 (6.9–10.4) | 0.601 | 9 (7.2–10.1) | 0.797 | 8.8 (7.1–9.5) | 0.608 | 7.4 (7–8.2) | 0.495 | 16.65 (14.03–17.58) | 0.972 | | LS + SS | 5.1 (4.7–5.6) | 8.9 (7.9–10.2) | 9 (7.4–11.1) | 8 (6.7–9.5) | 6.8 (5.8–8.6) | 16.08 (13.78–18.5) |
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