SLC6A4 5HTTLPR Polymorphism Affects Insulin Secretion in Patients with Polycystic Ovary Syndrome

Table 3

Serotonin system polymorphisms and blood insulin levels during OGTT.

Polymorphism

Fasting blood insulin (μU/mL)

Blood insulin; 30 min (μU/mL)

Blood insulin; 60 min (μU/mL)

Blood insulin; 90 min (μU/mL)

Blood insulin; 120 min (μU/mL)

AUC

Median (25%–75%)

Median (25%–75%)

Median (25%–75%)

Median (25%–75%)

Median (25%–75%)

Median (25%–75%)

5HTR1A rs6295

CC

10.35 (7.46–19.48)

0.729

64.75 (41.43–104.75)

0.786

87.95 (52.13–128)

0.461

90.55 (72.1–113.5)

0.886

79.65 (46.83–95.88)

0.547

159.76 (93.35–226.61)

0.740

CG + GG

11.8 (6.37–19.03)

74.05 (43.05–102.5)

98.5 (66.98–134)

80.75 (61.13–118.5)

72.6 (51.4–125.25)

144.26 (118.27–210.94)

5HTR1B rs13212041

TT

10.95 (7.32–17.95)

0.623

72.3 (4.38–99.25)

0.969

83.95 (59.98–123.25)

0.382

80.55 (61.48–110.5)

0.485

79.3 (55.6–114)

0.539

144.26 (110.79–198.46)

0.602

TC + CC

11.15 (5.02–20.1)

69.25 (41.6–128.75)

96.45 (60.78–208.5)

91.85 (58.83–180.5)

65.9 (46.38–109.5)

149.63 (108.86–290.86)

5HTTLPR

LL

10.7 (5.98–17.1)

0.657

45.8 (42–83.8)

0.056

75.8 (37.3–106)

0.030

79.9 (57–99.5)

0.192

65.6 (47.9–96.6)

0.400

121.53 (78.64–169.2)

0.021

LS + SS

11.4 (6.44–20)

90.9 (54.1–120)

102 (71–137)

94.4 (69.7–120)

82.4 (56–125)

174.98 (120.7–239.25)