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International Journal of Endocrinology
Volume 2018, Article ID 6484839, 11 pages
Review Article

Effectiveness of Coenzyme Q10 Supplementation for Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis

1Hunan University of Chinese Medicine, Changsha 410208, China
2Jiangxi Provincial People’s Hospital, Nanchang 330006, China

Correspondence should be addressed to Xiao-he Wu; moc.361@yzykhxw and Hui-yong Huang; moc.621@86yhgnauh

Received 15 March 2018; Accepted 26 July 2018; Published 16 September 2018

Academic Editor: Alberto Ferlin

Copyright © 2018 Shi-ying Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. To evaluate the effectiveness and safety of coenzyme Q10 for patients with type 2 diabetes mellitus (T2DM). Methods. Data from randomized controlled trials were obtained to assess the effects of coenzyme Q10 versus placebo or western medicine on patients with T2DM. The study’s registration number is CRD42018088474. The primary outcomes included glycosylated hemoglobin, fasting blood glucose, and fasting insulin. Result. Thirteen trials involving 765 patients were included. Compared with the control group, coenzyme Q10 may decrease the HbA1c (WMD −0.29; 95% CI −0.54, −0.03; ) and the fasting blood glucose (WMD −11.21; 95% CI −18.99, −3.43; ). For fasting insulin, there is also not strong evidence that confirms which one is better because there was no statistical difference (WMD −0.48; 95% CI −2.54, 1.57; ). Conclusion. Based on current evidence, coenzyme Q10 may assist glycemic control, decrease TG, and improve HDL-C in patients with T2DM.