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International Journal of Endocrinology
Volume 2018 (2018), Article ID 6710326, 7 pages
Research Article

Gender-Specific Risk of Central Compartment Lymph Node Metastasis in Papillary Thyroid Carcinoma

1Department of Endocrinology, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China
2Department of Otolaryngology-Head and Neck Surgery, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China

Correspondence should be addressed to Bingyin Shi

Received 24 July 2017; Accepted 12 December 2017; Published 11 March 2018

Academic Editor: Claudio Casella

Copyright © 2018 Yushi Sun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Our aim was to evaluate the impact of gender on the predictive factors of central compartment lymph node metastasis (CLNM) in papillary thyroid carcinoma (PTC). A retrospective study of 590 patients treated for PTC was performed. Univariate and multivariate analyses showed that gender (female; ), age (≥45 y; ), tumor size (>1 cm; ), and multifocality () were independent predictive factors of CLNM in PTC patients. Patients were divided into male group () and female group (). Age (≥45 y; ), T4 () and multifocality () were independent predictive risk factors of CLNM in male patients. As for female patients, age (≥45 y; ), tumor size (>1 cm; ), multifocality (), and microcalcification () were independently correlated with CLNM. The sensitivity of the multivariate model for predicting CLNM in male patients was 64.9%, specificity was 82.9%, and area under the ROC curve (AUC) was 0.764. As for female patients, the sensitivity was 55.7%, specificity was 77.9%, and AUC was 0.73. This study showed that the predictive factors of CLNM indeed varied according to gender. To have a more accurate evaluation of CLNM, different predictive systems should be used for male and female patients.