Research Article
Gender-Specific Risk of Central Compartment Lymph Node Metastasis in Papillary Thyroid Carcinoma
Table 4
Univariate analysis of the correlation between clinical factors of the primary tumor and rate of CLNM in male and female PTC patients.
| | CLNM () | Male | | CLNM () | Female | | | NCLNM () | NCLNM () |
| | Age at diagnosis, M (range) | 37 (9–78) | 47 (26–66) | <0.001 | 38 (12–79) | 47 (13–84) | <0.001 | | Age (<45 y/≥45 y) | 73/35
67.6%/32.4% | 19/25
43.2%/56.8% | 0.005 | 166/72
69.7%/30.3% | 78/122
39%/61% | <0.001 | | Hashimoto’s thyroiditis, present/absent | 10/98
9.2%/90.8% | 4/40
9.1%/90.9% | 1.0 | 43/195
18.1%/81.9% | 44/156
22%/78% | 0.304 | | TSH, μIU/mL, M (range) | 1.75 (0.07–7.27) | 1.45 (0.07–5.79) | 0.589 | 2.12 (0.07–26.5) | 1.96 (0.07–28.3) | 0.586 | | T4, μg/dL, M (range) | 8.34 (4.68–13.2) | 7.86 (5.25–12) | 0.026 | 8.03 (4.36–24.4) | 8.17 (3.3–15.1) | 0.892 | | T3, ng/mL, M (range) | 1.39 (0.82–2.55) | 1.42 (0.8–1.94) | 0.149 | 1.34 (0.5–2.48) | 1.33 (0.63–2.28) | 0.823 | | TGAB, %, M (range) | 3.84 (2.53–51.3) | 3.51 (2.45–43.1) | 0.423 | 4.79 (1.98–62.6) | 4.39 (1.82–63.7) | 0.408 | | TMAB, %, M (Range) | 2.96 (1.9–39.8) | 2.98 (1.69–29.7) | 0.654 | 3.61 (1.53–41.7) | 3.32 (2.01–44) | 0.237 | | Ultrasonographic characteristics of suspicious nodules | | | | | | | | Tumor size (≦1 cm/>1 cm) | 22/86
20.4%/79.6% | 13/31
29.5%/70.5% | 0.328 | 38/200
16%/84% | 66/134
33%/67% | <0.001 | | Multifocal/unifocal | 50/58
46.3%/53.7% | 14/30
31.8%/68.2% | 0.10 | 117/121
49.1%/50.9% | 78/122
39%/61% | 0.05 | | Bilateral/unilateral | 32/76
29.6%/70.4% | 10/34
22.7%/77.3% | 0.388 | 78/160
32.8%/67.2% | 56/144
28%/72% | 0.280 | | Margin (regular/irregular) | 36/65
35.6%/64.4% | 24/19
55.8%/44.2% | 0.012 | 93/129
41.9%/58.1% | 86/99
46.5%/53.5% | 0.352 | | Border (clear/obscure) | 51/52
49.5%/50.5% | 24/17
58.5%/41.5% | 0.488 | 112/116
49.1%/50.9% | 102/91
52.8%/47.2% | 0.446 | | Hypoechoic/Hyper or isoechoic calcification | 98/8
90.7%/9.3% | 41/2
95.3%/4.7% | 0.724 | 227/11
95.4%/4.6% | 191/9
95.5%/4.5% | 0.951 | | Non-/micro-/coarse calcification | 18/73/17
16.7%/67.6%/15.7% | 9/32/3
20.4%/72.7%/6.9% | 0.322 | 35/170/31
14.8%/72%/13.2% | 57/108/35
28.5%/54%/17.5% | <0.001 | Vascularization
None/low/middle/high | 0/28/26/25
0/35.4%/32.9%/31.7% | 1/14/11/8
2.9%/41.2%/32.4%/23.5% | 0.434 | 12/71/61/34
6.7%/39.9%/34.3%/19.1% | 13/61/57/21
8.6%/40.1%/37.5%/13.8% | 0.579 |
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CLNM: central lymph node metastases; NCLNM: central lymph node metastases negative; PTC: papillary thyroid cancer.
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