Research Article
Circulating MicroRNAs in Elderly Type 2 Diabetic Patients
Figure 2
Glycemic control statuses of the patients at baseline and 3 and 15 months after initiation of metformin + sitagliptin. All 40 patients in poor metabolic control were enrolled. HbA1c levels were evaluated after 3 and 15 months from the addition of sitagliptin. On the basis of HbA1c values, patients were divided into responders and nonresponders. All patients showed an initial metabolic response to therapy (t3), whereas after 15 months (t15), 34/40 were responders. Based on this information, patients were divided into five groups: (1) t0 responder samples (R-t0), (2) t0 nonresponder samples (NR-t0), (3) t3 responder samples (R-t3), (4) t15 responder samples (R-t15), and (5) t15 nonresponder samples (NR-t15). miRNA profiling was performed at baseline and after 15 months of sitagliptin addition.