MicroRNA and Microvascular Complications of Diabetes

Figure 2

MicroRNAs involved in renal fibrosis in diabetes. MicroRNAs (miRNAs) implicated in glomerular (cream-coloured area) and tubule-interstitial (light purple-coloured area) fibrosis in diabetes. The image shows miRNAs in red boxes that are modulated by TGF-β1 and directly control collagen/fibronectin expression, miRNAs in bronze boxes that enhance TGF-β1 signaling, and miRNAs in purple boxes that affect fibrosis independently of TGF-β1. Target genes are shown in orange boxes. Grey lines indicate induction, while red lines indicate suppression of miRNA expression. EMT: epithelial mesenchymal transition; MMT: mesangial cell to myofibroblast transition; CTNNBIP1: catenin beta interacting protein 1; TGF-β1: transforming growth factor-β1; TGFB-R1: transforming growth factor type 1 receptor; VEGF: vascular endothelial growth factor; CTGF: connective tissue growth factor.