Verification That Mouse Chromosome 14 Is Responsible for Susceptibility to Streptozotocin in NSY Mice

Figure 2

Schematic illustration of congenic mice. R1 possesses proximal and middle segments of NSY-Chr14 from the centromere to the recombinant position between D14Mit5 and D14Mit235. R2 mice possess the proximal segment of NSY-Chr14 from the centromere to the recombinant position between D14Mit186 and D14Mit59. Regions from NSY mice are shown in gray, and regions from C3H mice are shown in white. Arrows show each recombinant position. In parentheses, marker map positions from the centromere obtained from the Mouse Genome Database (http://www.informatics.jax.org). The diabetogenic loci (Nidd2.1n and Nidd2.2n) and the adiposity locus (Adp1n), which were reported in our previous study [19], and STZ-susceptibility locus, which was demonstrated in this study, are shown in black bars.